Association of Systemic Lupus Erythematosus with <i>C8orf13–BLK</i> and <i>ITGAM–ITGAX</i>

2008911 citationsJournal Articlebronze Open Access

Authors

Geoffrey Hom

Robert Graham

Barmak Modrek

Robert P. Kimberly · University of California, San Francisco

Ward Ortmann

Sophie Garnier · Uppsala University

Annette T. Lee · Northwell Health

Sharon A. Chung · University of California, San Francisco

Ricardo C. Ferreira

Abstract

We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.

Topics & Keywords

Cell Adhesion Molecules Research RNA regulation and disease Platelet Disorders and Treatments

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: New England Journal of Medicine

Volume 358, Issue 9, pp. 900-909

DOI: 10.1056/nejmoa0707865

Field-Weighted Citation Impact: 47.62