ERK1/2 MAP kinases in cell survival and apoptosis

2006655 citationsReview

Authors

Zhimin Lu · The University of Texas MD Anderson Cancer Center

Shuichan Xu · SignalRx Pharmaceuticals (United States)

Abstract

ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.

Topics & Keywords

Melanoma and MAPK Pathways Protein Kinase Regulation and GTPase Signaling Synthesis and biological activity

Publication Details

Published in: IUBMB Life

Volume 58, Issue 11, pp. 621-631

DOI: 10.1080/15216540600957438

Field-Weighted Citation Impact: 3.27

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ERK1/2 MAP kinases in cell survival and apoptosis

Authors

Abstract

Topics & Keywords

Publication Details