Albumin-Conjugated Corrole Metal Complexes: Extremely Simple Yet Very Efficient Biomimetic Oxidation Systems

2005279 citationsJournal Article

Authors

Atif Mahammed · Technion – Israel Institute of Technology

Zeev Gross · Technion – Israel Institute of Technology

Abstract

An extremely simple biomimetic oxidation system, consisting of mixing metal complexes of amphiphilic corroles with serum albumins, utilizes hydrogen peroxide for asymmetric sulfoxidation in up to 74% ee. The albumin-conjugated manganese corroles also display catalase-like activity, and mechanistic evidence points toward oxidant-coordinated manganese(III) as the prime reaction intermediate.

Topics & Keywords

Porphyrin and Phthalocyanine Chemistry Metal-Catalyzed Oxygenation Mechanisms Vanadium and Halogenation Chemistry

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Journal of the American Chemical Society

Volume 127, Issue 9, pp. 2883-2887

DOI: 10.1021/ja045372c

Field-Weighted Citation Impact: 13.30