Fast Whole-Brain Three-dimensional Macromolecular Proton Fraction Mapping in Multiple Sclerosis

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Authors

Vasily L. Yarnykh · University of Wisconsin–Madison

James D. Bowen · Neuroscience Institute

Alexey Samsonov · University of Wisconsin–Madison

Pavle Repovic · Neuroscience Institute

Angeli Mayadev · Neuroscience Institute

Peiqing Qian · Neuroscience Institute

Beena Gangadharan

Abstract

MPF macromolecular proton fraction mapping enables quantitative assessment of demyelination in normal-appearing brain tissues and shows primary clinical relevance of GM gray matter damage in MS multiple sclerosis . MPF macromolecular proton fraction outperforms MT magnetization transfer ratio and R1 in detection of MS multiple sclerosis -related tissue changes.

Topics & Keywords

Multiple Sclerosis Research Studies RNA regulation and disease Advanced MRI Techniques and Applications

Publication Details

Published in: Radiology

Volume 274, Issue 1, pp. 210-220

DOI: 10.1148/radiol.14140528

Field-Weighted Citation Impact: 4.43

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Fast Whole-Brain Three-dimensional Macromolecular Proton Fraction Mapping in Multiple Sclerosis

Authors

Abstract

Topics & Keywords

Publication Details