Breakthrough C. parapsilosis and C. guilliermondii blood stream infections in allogeneic hematopoietic stem cell transplant recipients receiving long-term caspofungin therapy

Since 2004, when caspofungin became available at our institution for empirical treatment of fever, we have been faced with the occurrence of candidemia due to unusual species, i.e. C. parapsilosis and C. guilliermondii , which have been reported to exhibit decreased susceptibility to echinocandins