Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 <sup>+</sup> T-Cell–Mediated Injury in the Heart

2007271 citationsJournal Article

Authors

Nir Grabie · Harvard University

Israel Gotsman · Harvard University

Rosa DaCosta · Harvard University

Hong Pang · Harvard University

George Stavrakis · Harvard University

Manish J. Butte · Harvard University

Mary Keir · Harvard University

Abstract

Myocardial PD-L1, mainly localized on endothelium, is critical for control of immune-mediated cardiac injury and polymorphonuclear leukocyte inflammation.

Topics & Keywords

Viral Infections and Immunology Research Neutrophil, Myeloperoxidase and Oxidative Mechanisms Atherosclerosis and Cardiovascular Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 116, Issue 18, pp. 2062-2071

DOI: 10.1161/circulationaha.107.709360

Field-Weighted Citation Impact: 4.03