Cross-Linked Actin Networks (CLANs) in the Trabecular Meshwork of the Normal and Glaucomatous Human Eye In Situ

This study showed for the first time that CLANs exist in cells of TM tissues from both normal and glaucomatous eyes that have not been manipulated by either tissue or organ culture procedures. It also provides quantitative data on CLAN prevalence in organized TM tissue, which indicates that CLANs are far more common than predicted (even from tissue culture) and there may be one in every cell in the glaucomatous TM in situ.