Effect of Ezetimibe Coadministered With Atorvastatin in 628 Patients With Primary Hypercholesterolemia

2003676 citationsJournal Article

Authors

Christie M. Ballantyne · Baylor College of Medicine

John Houri · Baylor College of Medicine

A Notarbartoló · Radiant Research (United States)

Lorenzo Melani · Radiant Research (United States)

Leslie Lipka · Radiant Research (United States)

Ramachandran Suresh · Baylor College of Medicine

Steven Sun

Abstract

Ezetimibe plus atorvastatin was well tolerated, with a safety profile similar to atorvastatin alone and to placebo. When coadministered with atorvastatin, ezetimibe provided significant incremental reductions in LDL-C and triglycerides and increases in HDL-C. Coadministration of ezetimibe and atorvastatin offers a well-tolerated and highly efficacious new treatment option for patients with hypercholesterolemia.

Topics & Keywords

Lipoproteins and Cardiovascular Health Pharmaceutical Economics and Policy Cancer, Lipids, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 107, Issue 19, pp. 2409-2415

DOI: 10.1161/01.cir.0000068312.21969.c8

Field-Weighted Citation Impact: 65.34