Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

19911,346 citationsJournal Articlebronze Open Access

Authors

G. S. Liu · University of South Alabama Medical Center

J D Thornton · University of South Alabama Medical Center

Donna M. Van Winkle · University of South Alabama Medical Center

A Stanley · University of South Alabama Medical Center

R A Olsson · University of South Alabama Medical Center

James M. Downey · University of South Alabama Medical Center

Abstract

We conclude that adenosine released during the preconditioning occlusion stimulates cardiac A1 receptors, which leaves the heart protected against infarction even after the adenosine has been withdrawn.

Topics & Keywords

Cardiac Ischemia and Reperfusion Cardiac Imaging and Diagnostics Cardiovascular Function and Risk Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 84, Issue 1, pp. 350-356

DOI: 10.1161/01.cir.84.1.350

Field-Weighted Citation Impact: 38.87