Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease

2003391 citationsJournal Articlebronze Open Access

Authors

John I. Gallin · National Institute of Allergy and Infectious Diseases

David W. Alling · Cardinal Glennon Children’s Medical Center

Harry L. Malech · National Institute of Allergy and Infectious Diseases

Robert Wesley · Cardinal Glennon Children’s Medical Center

Deloris E. Koziol · Cardinal Glennon Children’s Medical Center

Beatriz E. Marciano · National Institute of Allergy and Infectious Diseases

Abstract

Itraconazole prophylaxis appears to be an effective and well-tolerated treatment that reduces the frequency of fungal infections in chronic granulomatous disease, but monitoring for long-term toxic effects is warranted.

Topics & Keywords

Neutrophil, Myeloperoxidase and Oxidative Mechanisms Antifungal resistance and susceptibility Fungal Infections and Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 348, Issue 24, pp. 2416-2422

DOI: 10.1056/nejmoa021931

Field-Weighted Citation Impact: 4.94