ELECTROPHYSIOLOGIC AND RETINAL PENETRATION STUDIES FOLLOWING INTRAVITREAL INJECTION OF BEVACIZUMAB (AVASTIN)

2006353 citationsJournal Article

Authors

Jonathan Shahar · Tel Aviv University

Robert L. Avery · California Retina Consultants

Gad Heilweil · Tel Aviv University

Adiel Barak · Tel Aviv University

Esther Zemel

Geoffrey P. Lewis · University of California, Santa Barbara

P.T. Johnson · University of California, Santa Barbara

Abstract

Bevacizumab was found to be nontoxic to the retina of rabbits based on electrophysiologic studies. Full thickness retinal penetration may explain observed clinical effects of intravitreal bevacizumab. Although it is difficult to directly extrapolate to humans, our study supports the safe use of intravitreal bevacizumab injection.

Topics & Keywords

Retinal Diseases and Treatments Retinal Development and Disorders Retinal and Macular Surgery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Retina

Volume 26, Issue 3, pp. 262-269

DOI: 10.1097/00006982-200603000-00002

Field-Weighted Citation Impact: 51.89