<i>SLCO1B1</i> 521T→C functional genetic polymorphism and lipid‐lowering efficacy of multiple‐dose pravastatin in Chinese coronary heart disease patients

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Authors

Wei Zhang · Central South University

Bi‐Lian Chen · Central South University

Vural Özdemir · University of California, Irvine

Yijing He · Central South University

Gan Zhou · Central South University

Dao‐Di Peng · Central South University

Sheng Deng ·

Abstract

The 521T-->C polymorphism of SLCO1B1 appears to modulate significantly the total cholesterol-lowering efficacy of pravastatin in Chinese patients with CHD. Further studies are warranted to determine the extent to which SLCO1B1 genetic variation may contribute to resistance to pravastatin in Asian patients treated with standard doses of pravastatin.

Topics & Keywords

Drug Transport and Resistance Mechanisms Lipoproteins and Cardiovascular Health Pharmacogenetics and Drug Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Clinical Pharmacology

Volume 64, Issue 3, pp. 346-352

DOI: 10.1111/j.1365-2125.2007.02892.x

Field-Weighted Citation Impact: 3.75