Distinct Sets of Genetic Alterations in Melanoma

20052,667 citationsJournal Articlebronze Open Access

Authors

John A. Curtin · University of California, San Francisco

Jane Fridlyand · UCSF Helen Diller Family Comprehensive Cancer Center

Toshiro Kageshita · Kumamoto University

Hetal Patel · UCSF Helen Diller Family Comprehensive Cancer Center

Klaus J. Busam · Memorial Sloan Kettering Cancer Center

Heinz Kutzner · Dermatopathologie Friedrichshafen

Kwang‐Hyun Cho

Abstract

The genetic alterations identified in melanomas at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.

Topics & Keywords

Cutaneous Melanoma Detection and Management Cancer Genomics and Diagnostics Gene expression and cancer classification

Publication Details

Published in: New England Journal of Medicine

Volume 353, Issue 20, pp. 2135-2147

DOI: 10.1056/nejmoa050092

Field-Weighted Citation Impact: 39.12

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Distinct Sets of Genetic Alterations in Melanoma

Authors

Abstract

Topics & Keywords

Publication Details