Determination of ( <i>S</i> )-(+)- And ( <i>R</i> )-(-)-Ibuprofen Enantiomers in Human Plasma After Chiral Precolumn Derivatization By Reversed-Phase Lc–Esi-MS/MS

The method was successfully applied to a bioequivalence study in 34 healthy human subjects. The assay reproducibility was confirmed by reanalysis of 130 subject samples.