Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK

2010100 citationsJournal Article

Authors

Dafa Ding · Second Affiliated Hospital of Nanjing Medical University

You Na · Second Affiliated Hospital of Nanjing Medical University

Xiaomei Wu · Nanjing Traditional Chinese Medicine Hospital

Jiarong Xu · Second Affiliated Hospital of Nanjing Medical University

Aiguo Patrick Hu · Second Affiliated Hospital of Nanjing Medical University

Xiaolong Ye · Second Affiliated Hospital of Nanjing Medical University

Abstract

These findings suggest the possibility that resveratrol exerts antiproliferative, antihypertrophic effects by activating AMPK and reducing 4E-BP1 and S6 phosphorylation, thus suppressing the development and progression of DN.

Topics & Keywords

Sirtuins and Resveratrol in Medicine Autophagy in Disease and Therapy Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Nephrology

Volume 31, Issue 4, pp. 363-374

DOI: 10.1159/000300388

Field-Weighted Citation Impact: 3.16