Effects of genetic variation in the <i>P2RX7</i> gene on pharmacodynamics of a P2X<sub>7</sub> receptor antagonist: a prospective genotyping approach

201221 citationsJournal Articlebronze Open Access

Authors

Simon McHugh · Addenbrooke's Hospital

Shilina Roman

Sam R. Miller · Predict (France)

Sally Wetten

Charles Cox

Fredrik Karpe · University of Oxford

Abstract

Leukocyte P2X₇ receptors had significantly altered pharmacodynamic responses to a specific antagonist (GSK1370319A), directly related to SNP genotype.

Topics & Keywords

Adenosine and Purinergic Signaling Adolescent and Pediatric Healthcare Immune Cell Function and Interaction

Publication Details

Published in: British Journal of Clinical Pharmacology

Volume 74, Issue 2, pp. 376-380

DOI: 10.1111/j.1365-2125.2012.04200.x

Field-Weighted Citation Impact: 0.95

Command Palette

Effects of genetic variation in the <i>P2RX7</i> gene on pharmacodynamics of a P2X<sub>7</sub> receptor antagonist: a prospective genotyping approach

Authors

Abstract

Topics & Keywords

Publication Details