SUICIDE GENE THERAPY TOXICITY AFTER MULTIPLE AND REPEAT INJECTIONS IN PATIENTS WITH LOCALIZED PROSTATE CANCER

2000117 citationsJournal Article

Authors

Moshe Shalev · Baylor College of Medicine

Dov Kadmon · Children's Cancer Center

Bin S. Teh · Children's Cancer Center

E. Brian Butler · Baylor College of Medicine

Estuardo Aguilar-Córdova · Texas Children's Hospital

Timothy C. Thompson · Children's Cancer Center

James R. Herman

Abstract

Direct injection into the prostate of a replication defective adenovirus containing the HSV-tk gene followed by intravenous ganciclovir is safe even in repeat cycles.

Topics & Keywords

Prostate Cancer Treatment and Research Renal and related cancers Virus-based gene therapy research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Urology

Volume 163, Issue 6, pp. 1747-1750

DOI: 10.1016/s0022-5347(05)67534-9

Field-Weighted Citation Impact: 16.55