Hippocampal Myo-inositol and Cognitive Ability in Adults With Down Syndrome

200566 citationsJournal Articlebronze Open Access

Authors

Felix Beacher

Andy Simmons · Cognitive Neuroimaging Lab

Eileen Daly · NeuroDevelopment Center

Verinder Prasher · West Heath Hospital

Claire Adams · Psychiatry Research Trust

Maria Luisa Margallo-Lana · Royal College of Surgeons in Ireland

Robin G. Morris

Simon Lovestone

Abstract

Adults with DS have a significantly increased brain concentration of myo-inositol, and this is associated with reduced cognitive ability. Future studies are required to relate myo-inositol concentration in people with DS to brain development and increased risk for developing Alzheimer disease.

Topics & Keywords

Alzheimer's disease research and treatments Pancreatitis Pathology and Treatment Down syndrome and intellectual disability research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of General Psychiatry

Volume 62, Issue 12, pp. 1360-1360

DOI: 10.1001/archpsyc.62.12.1360

Field-Weighted Citation Impact: 0.80