Aging effects on DNA methylation modules in human brain and blood tissue

2012672 citationsJournal Articlegold Open Access

Authors

Steve Horvath · University of California, Los Angeles

Yafeng Zhang · University of California, Los Angeles

Peter Langfelder · University of California, Los Angeles

René S. Kahn · University Medical Center Utrecht

Marco P. Boks · University Medical Center Utrecht

Kristel van Eijk · University Medical Center Utrecht

Leonard H. van den Berg

Abstract

Overall, our analysis revealed a robustly defined age-related co-methylation module that is present in multiple human tissues, including blood and brain. We conclude that blood is a promising surrogate for brain tissue when studying the effects of age on DNA methylation profiles.

Topics & Keywords

Epigenetics and DNA Methylation Bioinformatics and Genomic Networks Health, Environment, Cognitive Aging

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Genome biology

Volume 13, Issue 10, pp. R97-R97

DOI: 10.1186/gb-2012-13-10-r97

Field-Weighted Citation Impact: 16.00