Circulating Tumor DNA as a Liquid Biopsy for Cancer

2014751 citationsReviewbronze Open Access

Authors

Ellen Heitzer · Medical University of Graz

Jochen B. Geigl · Medical University of Graz

Abstract

Although the analysis of ctDNA is a promising area, and despite all efforts to develop suitable tools for a comprehensive analysis of tumor genomes from plasma DNA, the liquid biopsy is not yet routinely used as a clinical application. Harmonization of preanalytical and analytical procedures is needed to provide clinical standards to validate the liquid biopsy as a clinical biomarker in well-designed and sufficiently powered multicenter studies.

Topics & Keywords

Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations Genetic factors in colorectal cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 61, Issue 1, pp. 112-123

DOI: 10.1373/clinchem.2014.222679

Field-Weighted Citation Impact: 23.89