Coagulation and Fibrinolytic Disturbances in Women with Polycystic Ovary Syndrome

201188 citationsJournal Article

Authors

Louise Mannerås-Holm · University of Gothenburg

Fariba Baghaei · University of Gothenburg

Göran Holm · University of Gothenburg

Per Olof Janson · University of Gothenburg

Claes Ohlsson · University of Gothenburg

Malin Lönn · University of Gothenburg

Elisabet Stener‐Victorin ·

Abstract

PCOS is characterized by a prothrombotic state, as reflected by increased PAI-1 activity and fibrinogen, without signs of dyslipidemia or a proinflammatory state. Low SHBG and high insulin may partly explain the BMI-independent difference in PAI-1 activity between women with PCOS and controls. High-sensitivity C-reactive protein and E-selectin may be involved in regulating fibrinogen in PCOS.

Topics & Keywords

Ovarian function and disorders Blood properties and coagulation Blood Coagulation and Thrombosis Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 96, Issue 4, pp. 1068-1076

DOI: 10.1210/jc.2010-2279

Field-Weighted Citation Impact: 8.11