Search for a command to run...
Annals of the New York Academy of SciencesVolume 534, Issue 1 p. 1-30 Carcinogenesis Studies: Results of 398 Experiments on 104 Chemicals from the U. S. National Toxicology Program J. E. HUFF, J. E. HUFF National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorE. E. McCONNELL, E. E. McCONNELL National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorJ. K. HASEMAN, J. K. HASEMAN National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorG. A. BOORMAN, G. A. BOORMAN National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorS. L. EUSTIS, S. L. EUSTIS National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorB. A. SCHWETZ, B. A. SCHWETZ National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorG. N. RAO, G. N. RAO National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorC. W. JAMESON, C. W. JAMESON National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorL. G. HART, L. G. HART National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorD. P. RALL, D. P. RALL National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this author J. E. HUFF, J. E. HUFF National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorE. E. McCONNELL, E. E. McCONNELL National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorJ. K. HASEMAN, J. K. HASEMAN National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorG. A. BOORMAN, G. A. BOORMAN National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorS. L. EUSTIS, S. L. EUSTIS National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorB. A. SCHWETZ, B. A. SCHWETZ National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorG. N. RAO, G. N. RAO National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorC. W. JAMESON, C. W. JAMESON National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorL. G. HART, L. G. HART National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this authorD. P. RALL, D. P. RALL National Institute of Environmental Health Sciences National Toxicology Program Research Triangle Park, North Carolina 27709Search for more papers by this author First published: June 1988 https://doi.org/10.1111/j.1749-6632.1988.tb30085.xCitations: 64AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Haseman, J. K., J. E. Huff, E. Zeiger & E. E. McConnell. 1987. Comparative results of 327 chemical carcinogenicity studies conducted by the National Cancer Institute and the National Toxicology Program. Environ. Health Perspect. 74: 229–235. 2 Haseman, J. K., E. C. Tharrington, J. E. Huff & E. E. McConnell. 1986. Comparison of site-specific and overall tumor incidence analyses for 81 recent National Toxicology Program carcinogenicity studies. Reg. Toxicol. Pharmacol. 6: 155–170. 3 Huff, J. E. 1982. Carcinogenesis bioassay results from the National Toxicology Program. Environ. Health Perspect. 45: 185–198. 4 Huff, J. E., S. L. Eustis & J. K. Haseman. 1988. Chemicals causing malignant, malignant and benign, or benign neoplasia in 113 recent NTP long-term carcinogenesis studies in rodents. Submitted for publication. 5 Maronpot, R. R., J. K. Haseman, G. A. Boorman, S. E. Eustis, G. N. Rao & J. E. Huff. 1987. Liver lesions in B6C3F, mice: The National Toxicology Program experience and position. Arch. Toxicol. Suppl. 10: 10–26. 6 Rall, D. P., M. D. Hogan, J. E. Huff, B. A. Schwetz & R. W. Tennant. 1986. Alternatives to using human experience in assessing health risks. Annu. Rev. Public Health. 8: 355–385. 7 Chu, K. C., C. Cueto & J. M. Ward. 1981. Factors in the evaluation of 200 National Cancer Institute carcinogen bioassays. J. Toxicol. Environ. Health 8: 251–280. 8 Griesemer, R. A. & C. Cueto. 1980. Toward a classification scheme for degrees of experimental evidence for the carcinogenicity of chemicals for animals 27: 259–281. In Molecular and Cellular Aspects of Carcinogen Screening Tests. D. Montesano, H. Bartsch & L. Tomatis, Eds.: IARC Scientific Publications. International Agency for Research on Cancer. Lyon , France . 9 Huff, J. E. & J. A. Moore. 1984. Carcinogenesis studies and experimental data interpretation/evaluation at the National Toxicology Program. In Industrial Hazards of Plastics and Synthetic Elastomers. J. Jarvisalo, P. Pfaffli & H. Vainio, Eds.: 43–64. Alan R. Liss. New York . 10 Rall, D. P. 1985. National Toxicology Program (NTP): Levels of evidence of carcino-genicity used to describe evaluative conclusions for NTP long-term toxicology and carcinogenesis studies; request for comments. Fed. Reg. 51: 2579–2582. 11 Rall, D. P. 1986. National Toxicology Program (NTP): Notice of modifications in the levels of evidence of carcinogenicity used to describe evaluative conclusions for NTP long-term toxicology and carcinogenesis studies. Fed. Reg. 51: 11843–11844. 12 IARC ad hoc Working Group. 1982. Chemicals, industrial processes and industries associated with cancer in humans, IARC monographs, 1 to 29, Supplement 4. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. International Agency for Research on Cancer. Lyon , France . 13 IARC. 1986. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Vol. 38: Tobacco smoking. Preamble: 15–34. International Agency for Research on Cancer. Lyon , France . 14 Tomatis, L. 1985. The contribution of epidemiological and experimental data to the control of environmental carcinogens. Cancer Lett. 26: 5–16. 15 Tomatis, L. 1986. The contribution of the IARC monographs program to the identification of cancer risk factors. This volume. 16 Huff, J. E., E. E. McConnell & J. K. Haseman. 1985. On the proportion of positive results in carcinogenicity studies in aminals. Letter to the Editor. Environ. Mutat. 7: 427. 17 Althouse, R., L. Tomatis, J. E. Huff & J. D. Wilbourn. 1979. Chemicals and industrial processes associated with cancer in humans. IARC Monographs, 1–20, Supplement 1, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. International Agency for Research on Cancer. Lyon , France . 18 Althouse, R., J. E. Huff, L. Tomatis & J. D. Wilbourn. 1980. An evaluation of chemicals and industrial processes associated with cancer in humans based on human and animal data, IARC Monographs, 1–20. Cancer Res. 40: 1–12. 19 National Toxicology Program (NTP). 1985. NTP fourth annual report on carcinogens, 1–601, National Toxicology Program, Research Triangle Park , NC . 20 IARC. 19721986. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Vols. 1–38. International Agency for Research on Cancer. Lyon , France . 21 National Cancer Institute (NCI). 19761980. NCI bioassay of "chemical" for possible carcinogenicity. Carcinogenesis Technical Report Series Nos. 2–200, 202–205. National Cancer Institute. Bethesda , MD . 22 NTP. 19801986. NTP toxicology and carcinogenesis studies of "chemical" (CAS No.) in F344/N rats and B6C3F1 mice (exposure route). Technical Report Series Nos. 201, 206–329. National Toxicology Program. Research Triangle Park , NC . 23 Wilbourn, J. D., L. Haroun, H. Vainio & R. Montesano. 1984. Identification of chemicals carcinogenic to man. Toxicol. Pathol. 12: 397–399. 23a Wilbourn, J., L. Haroun, E. Heseltine, J. Kaldor, C. Partensky & H. Vainio. 1986. Response of experimental animals to human carcinogens: An analysis based upon the IARC monographs programme. Carcinogenesis 7: 1853–1863. 24 National Academy of Sciences (NAS). 1977. Drinking water and health. In Chemical Contaminants: Safety and Risk Assessment: 19–62. National Academy of Sciences. Washington , DC . 25 Office of Science and Technology Policy (OSTP). 1985. Chemical Carcinogens: A Review of the Science and Its Associated Principles. Interagency Staff Group on Chemical Carcinogenesis. Office of Science and Technology Policy. Executive Office of the President. Fed. Reg. 50: 10371–10442. 26 Office of Technology Assessment (OTA). 1981. Assessment of Technologies for Determining Cancer Risks from the Environment. Office of Technology Assessment, Congress of the United States. Government Princing Office. Washington , DC . 27 Huff, J. E., J. K. Haseman, E. E. McConnell & J. A. Moore. 1986. The National Toxicology Program, toxicology data evaluation techniques, and long-term carcinogenesis studies. In Safety Evaluation of Drugs and Chemicals. W. E. Lloyd: 411–447. Hemisphere Publishing Co. Washington , DC . 28 Alden, C. J. & J. E. Huff. (1984). Guidelines for the preparation of NTP technical reports on toxicology and carcinogenesis studies. National Toxicology Program, National Institute of Environmental Health Sciences. Research Triangle Park , NC . 29 Jameson, C. W. 1984. Analytical chemistry requirements for toxicity testing of environmental chemicals. In Chemistry for Toxicity Testing. C. W. Jameson & D. B. Walters, Eds.: 3–14. Butterworth. Boston , MA . 30 Haseman, J. K., J. E. Huff & G. A. Boorman. 1984. Use of historical control data in carcinogenicity studies in rodents. Toxicol. Pathol. 12: 126–135. 31 Haseman, J. K., J. E. Huff, G. N. Rao, J. E. Arnold, G. A. Boorman & E. E. McConnell. 1985. Neoplasms observed in untreated and corn oil gavage control groups of F344'N rats and (CSFBL/6N/HeH)F, (B6C3F1) mice. J. Natl. Cancer Inst. 75: 975–984. 32 Maronpot, R. R. & G. A. Boorman. 1982. Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assessment. Toxicol. Pathol. 10: 71–80. 33 Boorman, G. A., C. Montgomery, Jr., J. Hardisty, S. Eustis, M. Wolfe & E. E. McConnell. 1985. Quality assurance in pathology for rodent toxicology and carcinogenicity tests. In Handbook of Carcinogen Testing. H. Milman & E. Weisburger, Eds.: 345–357. Noyes Publications. Park Ridge , NJ . 34 McConnell, E. E., H. A. Solleveld, J. A. Swenberg & G. A. Boorman. 1986. Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. J. Natl. Cancer Inst. 76: 283–289. 35 IARC. 1980. Long-term and short-term screening assays for carcinogens: A critical appraisal. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Supplement 2. International Agency for Research on Cancer. Lyon , France . 35a Montesano, R., H. Bartsch, H. Vainio, J. Wilbourn & H. Yamasaki, Eds. & R. A. Griesemer & S. Venitt, Main Rapporteurs. 1986. Long-Term and Short-Term Assays for Carcinogens: A Critical Appraisal (Report 1): 13–83. International Agency for Research on Cancer, Lyon, France. 36 Prasse, K., P. Hildebrandt & D. Dodd. 1986. Letter to the Editor from the Council of the American College of Veterinary Pathologists regarding their position on "blind" pathology. Toxicol. Appl. Pharmacol. 83: 184–185. 37 Kaplan, E. L. & P. Meier. 1958. Nonparametric estimation of incomplete observations. J. Am. Stat. Assoc. 53: 457–481. 38 Cox, D. R. 1972. Regression models and life tables. J. R. Stat. Soc. B34: 187–220. 39 Tarone, R. E. 1975. Tests for trend in life table analysis. Biometrika 62: 679–682. 40 Mantel, N. & W. Haenszel. 1959. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 22: 719–748. 41 Haseman, J. K. 1984. Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies. Environ. Health Perspect. 58: 385–392. 42 Armitage, P. 1971. Statistical methods in medical research. John Wiley. New York , NY . 43 Gart, J., K. Chu & R. Tarone. 1979. Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J. Natl. Cancer Inst. 62: 957–974. 44 Haseman, J. K., D. Crawford, J. E. Huff, G. A. Boorman & E. E. McConnell. 1984. Results from 86 two-year carcinogenicity studies conducted by the National Toxicology Program. J. Toxicol. Environ. Health, 14: 621–639. 45 Zwickey, R. E. & K. J. Davis. 1959. Carcinogenicity screening. In Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, Association of Food and Drug Officials of the United States. Editorial Committee, Baltimore , MD . 46 Weisburger, E. K. 1983. History of the Bioassay Program of the National Cancer Institute. Prog. Exp. Tumor Res. 26: 187–201. 47 NTP Ad Hoc Panel. 1984. Report of the ad hoc panel on chemical carcinogenesis testing and evaluation. Presented to the National Toxicology Program Board of Scientific Counselors. National Toxicology Program. Research Triangle Park , NC . 48 NAS. 1984. Toxicity Testing. Strategies to Determine Needs and Priorities. National Academy of Sciences. Washington , DC . 49 Browning, E. 1965. Toxicity and Metabolism of Industrial Solvents. Elsevier. Amsterdam . 50 B. K. Hoover, J. K. Baldwin, A. F. Uelner, C. E. Whitmire, C. L. Davies & D. W. Bristol, Eds. 1986. Managing Conduct and Data Quality of Toxicology Studies. Princeton Scientific Publishing Co. Princeton , NJ . 51 Rall, D. P. 1983. National Toxicology Program; Cancellation of the Technical Report on dichloromethane gavage studies. Fed. Reg. 48: 35508. 52 Huff, J. E. 1986. The value of in-life and retrospective data audits. In Hoover et al.50: 99–104. 53 Tomatis, L. 1979. The predictive value of rodent carcinogenicity tests in the evaluation of human risks. Annu. Rev. Pharmacol. 19: 511–530. 54 Rall, D. P. 1983. Cancer prevention: Setting priorities. (Letter to the editor). Science 222: 1072–1073. 55 Bailar, J. C., III & E. M. Smith. 1986. Progress against cancer N. Engl. J. Med. 314: 1226–1232. 56 Doll, R. 1984. Occupation cancer: Problems in interpreting human evidence. Ann. Occup. Hyg. 28: 291–305. Citing Literature Volume534, Issue1Living in a Chemical World: Occupational and Environmental Significance of Industrial CarcinogensJune 1988Pages 1-30 ReferencesRelatedInformation
Published in: Annals of the New York Academy of Sciences
Volume 534, Issue 1, pp. 1-30