A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery

2009352 citationsJournal Articlegreen Open Access

Authors

Todd Hoare · Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

Jesús Santamarı́a · Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

Gerardo F. Goya · Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

Silvia Irusta · Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

Debora Lin · Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine

Samantha Lau ·

Abstract

Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were noncytotoxic, were biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.

Topics & Keywords

Hydrogels: synthesis, properties, applications Micro and Nano Robotics Electrohydrodynamics and Fluid Dynamics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Nano Letters

Volume 9, Issue 10, pp. 3651-3657

DOI: 10.1021/nl9018935

Field-Weighted Citation Impact: 9.57