Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions

2011244 citationsJournal Article

Authors

James F. Hainfeld · Nanoprobes (United States)

Matthew J. O’Connor · Nanoprobes (United States)

F. Avraham Dilmanian · State University of New York

Daniel N. Slatkin · Nanoprobes (United States)

David J. Adams

Henry M. Smilowitz · UConn Health

Abstract

In this pre-clinical study, antibody-targeted 15 nm gold nanoparticles showed preferential uptake in cognate tumours, but even untargeted gold nanoparticles enhanced the visibility of tumour peripheries and enabled detection of millimetre-sized tumours. Micro-CT enabled quantification within various regions of a tumour.

Topics & Keywords

Nanoparticle-Based Drug Delivery Radiopharmaceutical Chemistry and Applications Advanced Electron Microscopy Techniques and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Radiology

Volume 84, Issue 1002, pp. 526-533

DOI: 10.1259/bjr/42612922

Field-Weighted Citation Impact: 13.43