ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma

1996201 citationsJournal Article

Authors

Masanori Onda · Tokyo University of Science

Satoru Matsuda · Tokyo University of Science

Shozo Higaki · Teikyo University

Takuo Iijima · The University of Tokyo

Junichi Fukushima · Teikyo University

Akira Yokokura · The University of Tokyo

Tatsuyoshi Kojima ·

Abstract

In 42% of the osteosarcomas, the tumor cells expressed ErbB-2. Expression of ErbB-2 was strongly correlated with early pulmonary metastasis and poor survival rate for the patient. These data suggest that ErbB-2 plays a significant role in aggressive tumor growth and in the promotion of metastatic potential in osteosarcomas. ErbB-2 in the osteosarcoma tissues would be a useful prognostic marker for patients.

Topics & Keywords

HER2/EGFR in Cancer Research Monoclonal and Polyclonal Antibodies Research Peptidase Inhibition and Analysis

UN Sustainable Development Goals

No povertyGood health and well-being

Publication Details

Published in: Cancer

Volume 77, Issue 1, pp. 71-78

DOI: 10.1002/(sici)1097-0142(19960101)77:1<71::aid-cncr13>3.0.co;2-5

Field-Weighted Citation Impact: 3.53