Asymmetric hydrogenation of a 4,4-diaryl-3-butenoate; a novel approach to sertraline

200337 citationsJournal Article

Authors

Lee T. Boulton · Dow Chemical (United Kingdom)

Abstract

The asymmetric hydrogenation of a selectively crystallised (E)-4,4-diaryl-3-butenoate with a rhodium-PhanePhos catalyst is described, providing an intermediate to the antidepressant sertraline.

Topics & Keywords

Asymmetric Hydrogenation and Catalysis Asymmetric Synthesis and Catalysis Surface Chemistry and Catalysis

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Organic & Biomolecular Chemistry

Volume 1, Issue 7, pp. 1094-1096

DOI: 10.1039/b301175p

Field-Weighted Citation Impact: 1.17