A SILAC-Based Screen for Methyl-CpG Binding Proteins Identifies RBP-J as a DNA Methylation and Sequence-Specific Binding Protein

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Authors

Stefanie J. J. Bartels · Radboud University Nijmegen

Cornelia G. Spruijt · University Medical Center Utrecht

Arie B. Brinkman · Radboud University Nijmegen

Pascal W.T.C. Jansen · University Medical Center Utrecht

Michiel Vermeulen · University Medical Center Utrecht

Hendrik G. Stunnenberg · Radboud University Nijmegen

Abstract

The here described SILAC/methyl-CpG pull-down constitutes a new approach to identify potential novel DNAme readers and will advance unraveling of the complete methyl-DNA interactome.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Genetics and Neurodevelopmental Disorders

Publication Details

Published in: PLoS ONE

Volume 6, Issue 10, pp. e25884-e25884

DOI: 10.1371/journal.pone.0025884

Field-Weighted Citation Impact: 3.46

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A SILAC-Based Screen for Methyl-CpG Binding Proteins Identifies RBP-J as a DNA Methylation and Sequence-Specific Binding Protein

Authors

Abstract

Topics & Keywords

Publication Details