Soluble L-selectin attenuates tumor necrosis factor-α-mediated leukocyte adherence and vascular permeability: A protective role for elevated soluble L-selectin in sepsis*

Soluble L-selectin decreases local inflammation-mediated leukocyte adherence and vascular leakage in vivo. The increased concentrations of soluble L-selectin in sepsis may represent a protective mechanism by which the host attempts to diminish the deleterious systemic effects of activated leukocytes during sepsis.