CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast‐like synoviocytes from rheumatoid arthritis patients

These data suggest that through modulation of the migration, proliferation, and MMP production by FLS, the chemokine system may play a more direct role in the destructive phase of RA than is currently suspected, and thus emphasize the relevance of chemokines and their receptors as potential therapeutic targets in this disease.