Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis

2006135 citationsJournal Articlegold Open Access

Authors

Nikos Oikonomou · Alexander Fleming Biomedical Sciences Research Center

Vaggelis Harokopos · Alexander Fleming Biomedical Sciences Research Center

Jonathan Zalevsky · Xencor (United States)

Christos Valavanis · Metaxa Hospital

Αnastasia Kotanidou · National and Kapodistrian University of Athens

David E. Szymkowski · Xencor (United States)

George Kollias

Abstract

These results suggest a primary detrimental role of soluble TNF in the pathologic cascade, separating it from the beneficial role of transmembrane TNF, and indicate the importance of assessing the efficacy of soluble TNF antagonists in the treatment of Idiopathic Pulmonary Fibrosis.

Topics & Keywords

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Occupational and environmental lung diseases Pleural and Pulmonary Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 1, Issue 1, pp. e108-e108

DOI: 10.1371/journal.pone.0000108

Field-Weighted Citation Impact: 5.03