Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy

2004168 citationsJournal Article

Authors

Fritz Zimprich · Ludwig Boltzmann Institute Applied Diagnostics

Raute Sunder‐Plaßmann · Ludwig Boltzmann Institute Applied Diagnostics

Elisabeth Stögmann · Ludwig Boltzmann Institute Applied Diagnostics

Andreas Gleiß · Ludwig Boltzmann Institute Applied Diagnostics

Assunta Dal‐Bianco · Ludwig Boltzmann Institute Applied Diagnostics

Alexander Zimprich · Ludwig Boltzmann Institute Applied Diagnostics

Abstract

The multidrug transporter P-glycoprotein is suspected of contributing to pharmacoresistance in temporal lobe epilepsy (TLE). To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance. They identified a common haplotype that when present in the homozygous state significantly increased the risk for pharmacoresistance.

Topics & Keywords

Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Epilepsy research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 63, Issue 6, pp. 1087-1089

DOI: 10.1212/01.wnl.0000141021.42763.f6

Field-Weighted Citation Impact: 7.48