Increased Sensitivity to Seizures in Mice Lacking Cellular Prion Protein

1999184 citationsJournal Articlebronze Open Access

Authors

Roger Walz · Universidade Federal do Rio Grande do Sul

Olavo B. Amaral · Universidade Federal do Rio Grande do Sul

Isabel Cristina Rockenbach · Universidade Federal do Rio Grande do Sul

Rafael Roesler · Universidade Federal do Rio Grande do Sul

Iván Izquierdo · Universidade Federal do Rio Grande do Sul

Ésper A. Cavalheiro · Fundação de Apoio à Universidade Federal de São Paulo

Abstract

Animals lacking cellular prion protein expression are more susceptible to seizures induced by various convulsant agents. This is perhaps the most striking alteration yet found in PrPc-null mice, who at first analysis appeared to be completely normal. A possible role for PrPc in chronic and idiopathic (familial), secondary, or cryptogenic epilepsies in humans remains to be investigated.

Topics & Keywords

Prion Diseases and Protein Misfolding Infectious Encephalopathies and Encephalitis Neurological diseases and metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Epilepsia

Volume 40, Issue 12, pp. 1679-1682

DOI: 10.1111/j.1528-1157.1999.tb01583.x

Field-Weighted Citation Impact: 2.58