Thyroid Receptor Ligands. 6. A High Affinity “Direct Antagonist” Selective for the Thyroid Hormone Receptor

200637 citationsJournal Articlegreen Open Access

Authors

Konrad F. Koehler · Karo Pharma (Sweden)

Sandra Gordon · Karo Pharma (Sweden)

Peter Brandt · Karo Pharma (Sweden)

Bo Carlsson · Karo Pharma (Sweden)

Anna Bäcksbro-Saeidi · Karo Pharma (Sweden)

T. Apelqvist · Karo Pharma (Sweden)

Peter Agback ·

Abstract

A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Medicinal Chemistry

Volume 49, Issue 23, pp. 6635-6637

DOI: 10.1021/jm060521i

Field-Weighted Citation Impact: 2.27