Reduced Mortality after Allogeneic Hematopoietic-Cell Transplantation

20101,469 citationsJournal Articlebronze Open Access

Authors

Ted Gooley · Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

Jason W. Chien · Cancer Research Center

Steven A. Pergam · Hutchinson (United Kingdom)

Sangeeta Hingorani · University of Washington

Mohamed L. Sorror · Fred Hutch Cancer Center

Michael Boeckh · Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

Abstract

We found a substantial reduction in the hazard of death related to allogeneic hematopoietic-cell transplantation, as well as increased long-term survival, over the past decade. Improved outcomes appear to be related to reductions in organ damage, infection, and severe acute GVHD. (Funded by the National Institutes of Health.).

Topics & Keywords

Hematopoietic Stem Cell Transplantation Renal Transplantation Outcomes and Treatments Acute Lymphoblastic Leukemia research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 363, Issue 22, pp. 2091-2101

DOI: 10.1056/nejmoa1004383

Field-Weighted Citation Impact: 41.41