Plasma Concentrations of o,p′DDD, o,p′DDA, and o,p′DDE as Predictors of Tumor Response to Mitotane in Adrenocortical Carcinoma: Results of a Retrospective ENS@T Multicenter Study

2011172 citationsJournal Articlebronze Open Access

Authors

I G C Hermsen · Máxima Medisch Centrum

Martin Faßnacht · University of Würzburg

Massimo Terzolo · University of Turin

Saskia Houterman · Máxima Medisch Centrum

Jan den Hartigh

Sophie Leboulleux · Institut Gustave Roussy

Fulvia Daffara · University of Turin

Abstract

Our data confirm the value of o,p'DDD plasma monitoring as well as targeting the 14 mg/liter cutoff level in the therapeutic management of ACC patients. Furthermore, our results suggest additional benefit of higher levels of o,p'DDD and combined measurement of o,p'DDD and o,p'DDA.

Topics & Keywords

Adrenal and Paraganglionic Tumors Cancer, Hypoxia, and Metabolism Pituitary Gland Disorders and Treatments

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 96, Issue 6, pp. 1844-1851

DOI: 10.1210/jc.2010-2676

Field-Weighted Citation Impact: 16.21

Command Palette

Plasma Concentrations of o,p′DDD, o,p′DDA, and o,p′DDE as Predictors of Tumor Response to Mitotane in Adrenocortical Carcinoma: Results of a Retrospective ENS@T Multicenter Study

Authors

Abstract

Topics & Keywords

Publication Details