Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

2014927 citationsJournal Article

Authors

Massimo S. Fiandaca · Georgetown University

Dimitrios Kapogiannis · Institute on Aging

Mark Mapstone · University of Rochester

Adam L. Boxer · University of California San Francisco Medical Center

Erez Eitan · National Institute on Aging

Janice B. Schwartz · University of California San Francisco Medical Center

Erin L. Abner

Abstract

Levels of P-S396-tau, P-T181-tau, and Aβ1-42 in extracts of neurally derived blood exosomes predict the development of AD up to 10 years before clinical onset.

Topics & Keywords

Alzheimer's disease research and treatments S100 Proteins and Annexins Neuroinflammation and Neurodegeneration Mechanisms

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Alzheimer s & Dementia

Volume 11, Issue 6, pp. 600-600

DOI: 10.1016/j.jalz.2014.06.008

Field-Weighted Citation Impact: 22.05