Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion

199992 citationsJournal Article

Authors

K. C. Nicolaou · University of California, San Diego

Janet L. Gunzner · University of California, San Diego

Guoqiang Shi · Scripps Research Institute

Konstantinos A. Agrios · Scripps Research Institute

Peter Gärtner · University of California, San Diego

Zhen Yang · University of California, San Diego

Abstract

A ten-year campaign was successfully completed by the first total synthesis of brevetoxin A (1). A Horner–Wittig type coupling of suitably functionalized BCDE and GHIJ ring systems proved to be the last key step in the total synthesis of this architecturally beautiful molecule.

Topics & Keywords

Synthetic Organic Chemistry Methods Oxidative Organic Chemistry Reactions Marine Toxins and Detection Methods

UN Sustainable Development Goals

Sustainable cities and communities

Publication Details

Published in: Chemistry - A European Journal

Volume 5, Issue 2, pp. 646-658

DOI: 10.1002/(sici)1521-3765(19990201)5:2<646::aid-chem646>3.0.co;2-e

Field-Weighted Citation Impact: 4.26