Stabilization of Hypoxia Inducible Factor Rather than Modulation of Collagen Metabolism Improves Cardiac Function After Acute Myocardial Infarction in Rats

200669 citationsJournal Article

Authors

Sebastian Philipp · Helios Kliniken

Jan Steffen Jürgensen · Friedrich-Alexander-Universität Erlangen-Nürnberg

Jens Fielitz · Helios Kliniken

Wanja M. Bernhardt · Friedrich-Alexander-Universität Erlangen-Nürnberg

Alexander Weidemann · Friedrich-Alexander-Universität Erlangen-Nürnberg

Astrid Schiche · Helios Kliniken

Bernhard Pilz

Abstract

Specific inhibition of the P4-H improved cardiac function without affecting the infarct size after experimental myocardial infarction in rats. Stabilization of HIF rather than inhibition of collagen maturation by P4-HI may prevent cardiac remodeling after MI.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Medical Imaging Techniques and Applications Cardiovascular Function and Risk Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Journal of Heart Failure

Volume 8, Issue 4, pp. 347-354

DOI: 10.1016/j.ejheart.2005.10.009

Field-Weighted Citation Impact: 2.54