p16 Protein Expression and Human Papillomavirus Status As Prognostic Biomarkers of Nonoropharyngeal Head and Neck Squamous Cell Carcinoma

2014376 citationsJournal Article

Authors

Christine H. Chung · University of Wisconsin Carbone Cancer Center

Qiang Zhang · University of Wisconsin Carbone Cancer Center

Christina S. Kong · University of Wisconsin Carbone Cancer Center

Jonathan Harris · University of Wisconsin Carbone Cancer Center

Elana J. Fertig · University of Wisconsin Carbone Cancer Center

Paul M. Harari · University of Wisconsin Carbone Cancer Center

Abstract

Similar to results in patients with OPSCC, patients with p16-negative non-OPSCC have worse outcomes than patients with p16-positive non-OPSCC, and HPV may also have a role in outcome in a subset of non-OPSCC. However, further development of a p16 IHC scoring system in non-OPSCC and improvement of HPV detection methods are warranted before broad application in the clinical setting.

Topics & Keywords

Head and Neck Cancer Studies Colorectal and Anal Carcinomas Cancer-related Molecular Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 32, Issue 35, pp. 3930-3938

DOI: 10.1200/jco.2013.54.5228

Field-Weighted Citation Impact: 39.86