Pharmacokinetics and pharmacodynamics of recombinant factor VIIa

1994255 citationsJournal Article

Authors

Celeste Lindley · University of North Carolina at Chapel Hill

William T. Sawyer · University of North Carolina at Chapel Hill

B. Gail Macik · University of North Carolina at Chapel Hill

Jean Lusher · Children's Hospital of Michigan

Justin F Harrison · Children's Hospital of Michigan

Kelly Baird-Cox · University Hospital of Wales

Kel Birch

Abstract

The pharmacokinetics of rFVIIa are linear in the dose range evaluated. The results suggest potential value of prothrombin time determination in the monitoring of rFVIIa therapy.

Topics & Keywords

Hemophilia Treatment and Research Blood Coagulation and Thrombosis Mechanisms Platelet Disorders and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 55, Issue 6, pp. 638-648

DOI: 10.1038/clpt.1994.80

Field-Weighted Citation Impact: 0.93