Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

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Authors

Thomas H. Sisson · University of Michigan

Michael Mendez · Veterans Health Administration

Eun-Young Choi · University of Michigan

Natalya Subbotina · University of Michigan

Anthony J. Courey · University of Michigan

Andrew K. Cunningham · University of Michigan

Aditi K. Dave ·

Abstract

The development of lung fibrosis in the setting of type II cell injury in our model provides evidence for a causal link between the epithelial defects seen in idiopathic pulmonary fibrosis and the corresponding areas of scarring.

Topics & Keywords

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Pleural and Pulmonary Diseases Neonatal Respiratory Health Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 181, Issue 3, pp. 254-263

DOI: 10.1164/rccm.200810-1615oc

Field-Weighted Citation Impact: 15.29