New Anti–Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E–Knockout Mice

2001243 citationsJournal Articlebronze Open Access

Authors

Weihua Ni · Kyushu University

Kensuke Egashira · Kyushu University

Shiro Kitamoto · Kyushu University

Chu Kataoka · Kyushu University

Masamichi Koyanagi · Kyushu University

Shujiro Inoue · Kyushu University

Katsumi Imaizumi · Kyushu University

Abstract

We conclude that this anti-MCP-1 gene therapy may serve not only to reduce atherogenesis but also to stabilize vulnerable atheromatous plaques. This strategy may be a useful and feasible form of gene therapy against atherosclerosis in humans.

Topics & Keywords

Atherosclerosis and Cardiovascular Diseases interferon and immune responses Nuclear Receptors and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 103, Issue 16, pp. 2096-2101

DOI: 10.1161/01.cir.103.16.2096

Field-Weighted Citation Impact: 6.34