Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol

200856 citationsJournal Articlebronze Open Access

Authors

Clóvis Orlando da Fonseca · Hospital Universitário Antônio Pedro

Rafael Linden · Universidade Federal do Rio de Janeiro

Débora Omena Futuro · Universidade Federal Fluminense

Cerli Rocha Gattass · Universidade Federal do Rio de Janeiro

Thereza Quírico‐Santos · Universidade Federal Fluminense

Abstract

The preliminary results indicate that intranasal administration of the signal transduction inhibitor POH is a safe, noninvasive, and low-cost method. There were no toxicity events and the regression of tumor size in some patients is suggestive of antitumor activity.

Topics & Keywords

Glioma Diagnosis and Treatment Retinoids in leukemia and cellular processes Brain Metastases and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archivum Immunologiae et Therapiae Experimentalis

Volume 56, Issue 4, pp. 267-276

DOI: 10.1007/s00005-008-0027-0

Field-Weighted Citation Impact: 1.61