Cytotoxic Hypothemycin Analogues from <i>Hypomyces subiculosus</i>

200645 citationsJournal Article

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Abstract

Three new hypothemycin analogues were isolated from the fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The structures of these compounds were elucidated by spectroscopic methods, chemical conversion, and X-ray crystallographic analysis. One of the analogues, 4-O-demethylhypothemycin, exhibited potent and selective cytotoxic activity against cell lines with a BRAF mutation.

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Microbial Natural Products and Biosynthesis 14-3-3 protein interactions Chemical Synthesis and Analysis

Publication Details

Published in: Journal of Natural Products

Volume 69, Issue 10, pp. 1456-1459

DOI: 10.1021/np060258o

Field-Weighted Citation Impact: 1.39

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Cytotoxic Hypothemycin Analogues from <i>Hypomyces subiculosus</i>

Authors

Abstract

Topics & Keywords

Publication Details