A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

2013291 citationsJournal Articlebronze Open Access

Authors

Juan Sandoval

Jesús Méndez‐González

Montse Sánchez‐Céspedes

Yassen Assenov · Max Planck Institute for the Study of Societies

Abstract

The DNA methylation signature of NSCLC affects the outcome of stage I patients, and it can be practically determined by user-friendly polymerase chain reaction assays. The analysis of the best DNA methylation biomarkers improved prognostic accuracy beyond standard staging.

Topics & Keywords

Epigenetics and DNA Methylation RNA modifications and cancer Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 31, Issue 32, pp. 4140-4147

DOI: 10.1200/jco.2012.48.5516

Field-Weighted Citation Impact: 13.63