Induction of Epithelial–Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-β1

2009372 citationsJournal Article

Authors

Tillie‐Louise Hackett · University of British Columbia

Stephanie Warner · St. Paul's Hospital

Dorota Stefanowicz · St. Paul's Hospital

Furquan Shaheen · St. Paul's Hospital

Dmitri V. Pechkovsky · University of British Columbia

Lynne A. Murray · Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic

Rochelle L. Argentieri

Abstract

TGF-beta1 induces EMT in a Smad3-dependent manner in primary AECs. However, in asthmatic-derived ALI-AEC cultures, the number of cells undergoing EMT is greater. These findings support the hypothesis that epithelial repair in asthmatic airways is dysregulated.

Topics & Keywords

Cancer Cells and Metastasis Neonatal Respiratory Health Research Asthma and respiratory diseases

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 180, Issue 2, pp. 122-133

DOI: 10.1164/rccm.200811-1730oc

Field-Weighted Citation Impact: 10.94

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Induction of Epithelial–Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-β1

Authors

Abstract

Topics & Keywords

Publication Details