¹¹C‐labeled octanal and benzaldehyde

Abstract The synthesis of octanal and benzaldehyde, labeled with 11 C in the carbonyl position, is reported. Octanal was prepared via an insertion reaction of 11 CO into the boroncarbon bond of B‐heptyl‐9‐BBN, followed by oxidative hydrolysis. Benzaldehyde was synthesized by the reaction of phenyl magnesium bromide with 11 CO 2 , and subsequent reduction of the labeled benzoic acid to benzylalcohol which was then oxidized to the final product by CrO 2 Cl 2 . Both aldehydes were purified via GLPC, leading to radiochemical purities of > 99.5% in each case. The radiochemical yield for octanal and benzaldehyde was 30 ± 5% and 15 ± 5%, respectively. The overall synthesis time was 50 ± 10 min for each compound.