Desensitization in HLA-Incompatible Kidney Recipients and Survival

2011667 citationsJournal Articlebronze Open Access

Authors

Robert A. Montgomery · Johns Hopkins University

Bonnie E. Lonze · Johns Hopkins University

Karen E. King · Johns Hopkins University

Edward S. Kraus · Johns Hopkins University

Lauren M. Kucirka · Johns Hopkins University

Jayme E. Locke · Johns Hopkins University

Daniel Warren ·

Abstract

Live-donor transplantation after desensitization provided a significant survival benefit for patients with HLA sensitization, as compared with waiting for a compatible organ. By 8 years, this survival advantage more than doubled. These data provide evidence that desensitization protocols may help overcome incompatibility barriers in live-donor renal transplantation. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and the Charles T. Bauer Foundation.).

Topics & Keywords

Renal Transplantation Outcomes and Treatments Organ Donation and Transplantation Organ Transplantation Techniques and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 365, Issue 4, pp. 318-326

DOI: 10.1056/nejmoa1012376

Field-Weighted Citation Impact: 35.64