Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats

2014168 citationsJournal Articlegold Open Access

Authors

Gu Gong · Chengdu Military General Hospital

Lei Xiang · Tianjin Huanhu Hospital

Libang Yuan · Xijing Hospital

Ling Hu · Chengdu Military General Hospital

Wei Wu · Chengdu Military General Hospital

Lin Cai · Chengdu Military General Hospital

Liang Yin ·

Abstract

GL has a protective effect on ischemia-reperfusion injury in rat brains through the inhibition of inflammation, oxidative stress and apoptotic injury by antagonising the cytokine activity of HMGB1.

Topics & Keywords

Advanced Glycation End Products research Neurological Disease Mechanisms and Treatments Neuroinflammation and Neurodegeneration Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 9, Issue 3, pp. e89450-e89450

DOI: 10.1371/journal.pone.0089450

Field-Weighted Citation Impact: 9.79