Single-Dose Pharmacokinetics of Daptomycin in Children With Suspected or Proved Gram-Positive Infections

200874 citationsJournal Article

Authors

Susan M. Abdel‐Rahman · University of Missouri–Kansas City

David P. Benziger · Cubist Pharmaceuticals (United States)

Richard F. Jacobs · University of Arkansas for Medical Sciences

Hasan S. Jafri · The University of Texas Southwestern Medical Center

Erica Fischer Hong · Cubist Pharmaceuticals (United States)

Gregory L. Kearns · Children's Mercy Hospital

Abstract

Systemic drug exposure after a single weight-adjusted daptomycin dose is reduced in younger children compared with adolescents and adults consequent to an apparent age-associated change in total plasma clearance.

Topics & Keywords

Antibiotics Pharmacokinetics and Efficacy Antimicrobial Resistance in Staphylococcus Antibiotic Resistance in Bacteria

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Pediatric Infectious Disease Journal

Volume 27, Issue 4, pp. 330-334

DOI: 10.1097/inf.0b013e318160edfc

Field-Weighted Citation Impact: 3.41